Intermittent performance degradation for remote clients connected to databases when Windows RSS, RSC, Windows Interrupt Moderation features among others are enabled on Windows Servers 

Performance is intermittently degraded for clients (_proapsv, _progress, prowin, _mproapsv) are connected to a remote database when Windows TCP segment aggregation and moderation features are enabled.

Client-Networking Applications perform poorly on specific sites hosting databases on Windows Servers

Clients with Netsetup installation perform slow since moving to Windows Server 2019.

Connections to new Windows servers show clients take a lot longer to read the same data

Two or more processes accessing the network take less time than either process running alone when nothing else is using the network.
A remote query that returns the same result set randomly runs slower

OpenEdge Replication connection interrupts and overall latency has increased on the new Windows Server

Database and client startup parameters are the same.
Local installation of Client Networking did not improve performance.

Several Windows Network TCP/IP features and related NIC settings are enabled, that degrade network response and overall performance. These features are typically tuned for streaming not database packets.

• Windows Receive Side Scaling (RSS)
• Receive Segment Coalescing (RSC) 
• Windows Interrupt Moderation 
• TCP Offloading
• TCP Large Send Offload
• Jumbo Frames/Jumbo Packets enabled devices
• IPsec Task Offload or TCP Chimney Offload (deprecated in Windows Server 2016)

Additionally packets can be dropped when one device is not configured/does not support these features. For example TCP/IP features common for Windows Server 2019 and Windows 10 but not for earlier versions.
 

There is no universal guidance on this topic and it is not one that technical support can necessarily assist with.

Updates from customers experiencing these client/server performance issues have reported that disabling Windows Receive Side Scaling (RSS) and Windows Interrupt Moderation on the client and Database Server machines have helped stop intermittent poor query performance.

Specific to Windows Server 2019 a default configuration change was introduced called Receive Segment Coalescing (RSC) TCP segment aggregation, that combines segments in order to process larger segments versus multiple small segments.  Customers have seen performance improvements when disabling the RSC on the driver of the network adapter of the Windows Server 2019.  This can be done as follows: 

1) Open a Powershell command prompt as Administrator
2) Run the following command:  disable-netadapterrsc *

The following VMWare Customer Connect link provides more detailed information for this work around to any performance degradation by disabling RSC:  
https://kb.vmware.com/s/article/2129176

It is recommended to engage Network specialists to assist in best resolving this according to site-specific topology.  The following forum documents these in the more recent Windows 2019 Server, which if nothing less helps to understand the complex relations of these and why they're affecting OpenEdge application network performance.

References to Other Documentation:

Performance Tuning Network Adapters
https://docs.microsoft.com/en-US/windows-server/networking/technologies/network-subsystem/net-sub-performance-tuning-nics
Receive Side Scaling
https://docs.microsoft.com/en-us/windows-hardware/drivers/network/receive-side-scaling-version-2-rssv2-
Interrupt Moderation
https://docs.microsoft.com/en-us/windows-hardware/drivers/network/interrupt-moderation  
Receive Segment Coalescing
https://docs.microsoft.com/en-us/windows-hardware/drivers/network/overview-of-receive-segment-coalescing

powershell to disable Receive Side Scaling: https://community.spiceworks.com/topic/2225989-server-2019-network-performance?page=8#entry-8745935  
powershell to set the NUMA assignment for NICS: https://community.spiceworks.com/topic/2225989-server-2019-network-performance?page=9#entry-8845561  

Windows Server 2016 Networking – Part 3- Optimizing Network settings
https://www.darrylvanderpeijl.com/windows-server-2016-networking-optimizing-network-settings/