Every cell in the body produces cholesterol. Additional cholesterol, received through the diet, is absorbed
by the small intestine. Both synthesized and absorbed cholesterol play a role in atherosclerosis
development as it all, sooner or later, ends up in LDL.
Blocking cholesterol synthesis with a statin lowers LDL cholesterol as does blocking cholesterol
absorption with an inhibitor like Ezetimibe (otherwise it’s repetitive). Every person is different when it
comes to cholesterol balance. Some people synthesize cholesterol more than they absorb, while others
absorb more than they synthesize. Knowing whether a patient is a hyper synthesizer or a hyper absorber
allows for better treatment as response to drug therapy varies accordingly. A synthesizer responds well to
a statin while a hyper absorber may benefit more from combination therapy with Ezetimibe. Knowing what
therapy works best in advance will allow for a more successful and cost effective treatment strategy.
Lathosterol, the direct precursor of cholesterol, can be measured in plasma or serum. Eighty percent of
synthesized cholesterol goes through lathosterol, while only 20% goes through desmosterol. Therefore
lathosterol is the only valid marker of cholesterol production. People who overproduce cholesterol have
elevated levels of lathosterol normalized to total blood cholesterol levels. Markedly elevated levels of
lathosterol identify patients with increased risk of premature coronary heart disease.
This decision service analyzes lab results to determine risk and lifestyle and therapy options