There is no universal guidance on this topic and it is not one that technical support can necessarily assist with.
Updates from customers experiencing these client/server performance issues have reported that disabling Windows Receive Side Scaling (RSS) and Windows Interrupt Moderation on the client and Database Server machines have helped stop intermittent poor query performance.
Specific to Windows Server 2019 a default configuration change was introduced called Receive Segment Coalescing (RSC) TCP segment aggregation, that combines segments in order to process larger segments versus multiple small segments. Customers have seen performance improvements when disabling the RSC on the driver of the network adapter of the Windows Server 2019. This can be done as follows:
1) Open a Powershell command prompt as Administrator
2) Run the following command: disable-netadapterrsc *
The following VMWare Customer Connect link provides more detailed information for this work around to any performance degradation by disabling RSC:
https://kb.vmware.com/s/article/2129176It is recommended to engage Network specialists to assist in best resolving this according to site-specific topology. The following forum documents these in the more recent Windows 2019 Server, which if nothing less helps to understand the complex relations of these and why they're affecting OpenEdge application network performance.
